Welcome to the FESNov catalog explorer

Here, we analyzed a global multi-habitat dataset covering 169,484 genomes assembled from environmental samples and compiled a highly curated set of 404,085 functionally and evolutionary significant novel (FESNov) gene families, nearly tripling the knowledge base of known prokaryotic orthologous groups described to date.

FESNov gene families identified spread out across the prokaryote phylogeny, span multiple habitats, and contain new protein domains that are under strong purifying selection. Using genomic context analysis, structural alignments and intrinsic sequence signatures, we predicted functional roles of 32.4% the the FESNov families, including high-confidence associations with processes such as energy production, xenobiotic degradation, signaling and antimicrobial resistance pathways.

You can use this online browser to query FESNov gene families associated with specific KEGG pathway or including specific taxa.